Thenga iCroda ngendima yayo ebalulekile emithini yokugoma iCovid mRNA

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I-Croda International (CRDA), inkampani yamakhemikhali yase-UK, izwakala njengesitokisi sezimboni ezinothuli - hhayi okuthokozisayo kakhulu kepha okuholela ngokuqinile nokukhokhela izinzuzo. I-Well Croda ngokuqinisekile ikhokha isabelo, yize isivuno esiphansi sika-1.7% nemali etholwayo ihambisana futhi ibikezela, futhi ibikade ikhuphukile ekukhuleni eminyakeni embalwa edlule.

Kepha okubheka iso ngeCroda kungumgogodla wayo ophathelene nesayensi yezempilo, naleyo ngxenye yokusebenza kwenkampani ithatha ukubaluleka okukhulu kwesikhathi sekwephuzile, lapho inkampani ivele njengomhlinzeki obaluleke kakhulu wezithasiselo zemithi yokugoma, ikakhulukazi i-mRNA (messenger RNA) Okusekwe ezenzelwe ukulwa noCovid-19.

Ngemuva kwesivumelwano seminyaka emihlanu esenziwe nePfizer emuva ngoNovemba nyakenye sokuphakela izithasiselo ezine zezidakamizwa, ezaziwa ngokuhlanganyela njengezikhiphi, inani lamasheya selithathe impilo entsha.

Izithasiselo yizithako ezingezona ezisebenzayo ezidakamizweni futhi zenza okuphakathi noma imoto yokuthola isithako esisebenzayo ezingxenyeni zomzimba lapho kudingeka khona.

AbakwaCroda bacabanga ukuthi inkontileka nePfizer ibiza cishe amaRandi ayizigidi eziyi-100 kulo nyaka kuphela ngesisekelo sokuthi iPfizer ihambise imithamo yokugoma ye-Covid eyi-1.3 billion ngonyaka we-2021.

Ikakhulu, izinto ezixhaswa yiCroda zifaka indawo entsha yezokwelapha ebizwa nge-solid lipid nanoparticles (SLNs) noma i-lipid nanoparticles (LNPs), futhi yenzelwe ukunika amandla imijovo yokungena emangqamuzaneni. Le ndlela yenoveli yokwakhiwa yamukelwa ukusetshenziswa ngo-2018.

Ama-lipid nanoparticles ahlala esimweni esiqinile ekamelweni nasekushiseni komzimba - ayizakhi zokwakheka kweseli futhi afaka izinto ezinjengamafutha namafutha. Izinhlayiya ziba ngosayizi kusuka ku-50 kuye ku-1000 nm. Ngomqondo wokuthi amancane kangakanani ama-nanoparticles, i-nanometer eyodwa ilingana no-0.0000001 millimeter.

Izabelo zeCroda emqulwini

Amasheya enkampani ekhethekile yamakhemikhali akhuphuke ngo-10% ngoNovemba ezindabeni zokuwina kwenkontileka yePfizer.

Ama-nanoparticles avimbela ukuthi i-ingredent esebenzayo, ngakolunye uhlangothi, ibhujiswe ngumzimba lapho ungena ngakolunye uhlangothi inika amandla umuthi ukungena kumaseli aphilayo, ngakho-ke yizinto ezibalulekile zokwakhiwa kwezidakamizwa zesizukulwane esisha.

Imithi yokwelapha esekwe kwi-RNA (ne-DNA) ibaluleke kakhulu embonini yezidakamizwa, ngempumelelo yemithi yokugoma ye-mRNA yeCovid eyisibonelo esihle kunazo zonke kuze kube manje. Abekho abadlali abaningi emkhakheni we-SLN / LNP kanti iCroda iphakathi kwabakhiqizi abakhulu.

Ngokungafani nabakhiphi bendabuko, kunenkinga enkulu kakhulu ebandakanyekile enqubeni yokuxuba kanye nezindawo ezinjengokuhlunga nokuzinza. Lezi ngezinye zezizathu zokuthi kungani abenzi bezidakamizwa bengagijimisanga ukusebenzisa ama-LNP, kepha ngemithi esekwe ku-mRNA, RNA kanye ne-siRNA eyinkimbinkimbi kakhulu, ayikho enye indlela. Impumelelo yemithi yokugoma i-Pfizer-Biontech ne-Moderna ye-Covid isivule insimu ngendlela emangalisayo.

Njengamanje kunabantu abangu-12 be-mRNA abagomela umuthi wokuthuthuka noma abasesigabeni sokuhlolwa komtholampilo, ngokusho kweWorld Health Organisation.

Ngokombono wabatshalizimali ngaleso sikhathi, iCroda inendlela enkulu yokukhula ephambi kwayo, evumela inani layo lamanje eliphakeme njengoba kulinganiswa ngenani lalo kumthamo wokuzuza wama-37.5; futhi ngemuva kokuthi i-spur yayo kaNovemba ihweba ngo-1.4% ngaphezu kwenani lentengo yabahlaziyi be-broker ye-6476p - ngesikhathi sokubhala amasheya weCroda athengwa ngo-6655p, enyuka ngo-1.3% namuhla.

Ukumba imiphumela yenkampani yokuphela konyaka kuze kube ngumhla zingama-31 kuZibandlela wezi-2020, imali engenayo inyuse inani elincane elingu-1% laya ku- £ 1.39 billion, kuyilapho imali isiyonke yehle yaya ku-10% yaya ku- £ 201 million.

Kodwa-ke, lezo zibalo zifihla umnikelo owenziwa yingxenye yeLife Sciences, eyenyuse imali engenayo ngo-15% yaya ku- £ 401 million.

Imali engenayo idonswe kakhulu yingxenye yebhizinisi le-Personal Care, ebhalise ukwehla kwe-16% kuya ku- £ 136 million.

Inzuzo yangaphambi kwentela yehlele ku- £ 269 million uma kuqhathaniswa ne- £ 302.3 million ngonyaka owedlule, kuyilapho inzuzo ngayinye yayiyi-171p ngo-2020 futhi ibikezelwa ku-200p kulo nyaka naku-221p ngo-2022.

I-Croda's LNP iwina kulandela ukuthengwa kwayo kwe-Avanti ne-Iberchem ngonyaka owedlule kwizivumelwano ezibandakanya inhlanganisela yezikweletu nokufakwa kwemali. I-Spanish frgracences kanye nama-flavour firm Iberchem (ithengwe ngo- £ 736 million) iqinisa amakhono akhona okwakhiwa kweCroda kanti u-Avanti ungumholi ekulethweni kwezidakamizwa esebenzisa ama-nanoparticles.

Ukutholwa bekuyingxenye yesiphakamiso esishiwo ngabaphathi 'sokusebenzisa isayensi ehlakaniphile ukwenza ngcono izimpilo' futhi ibeke inkampani ukuba ngumdlali ophambili esikhathini esizayo sokulethwa komuthi.

ICroda ukuthenga okunamandla.

Ungathenga iCroda ngekhomishini engu-0% epulatifomu lotshalo-mali lomhlaba wonke i-eToro.