Thenga iCroda ngendima yayo ephambili kwizitofu zeCovid mRNA

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Imirhumo yenyanga iqala kwi-£58.

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I-Croda International (CRDA), inkampani yeekhemikhali zase-UK, ivakala ngathi isitokhwe semizi-mveliso enothuli - ayiniki mdla kakhulu kodwa ifumana umvuzo ozinzileyo kunye nomhlawuli wezabelo. Ewe, iCroda ngokuqinisekileyo ihlawula isahlulo, nangona isivuno esiphantsi se-1.7% kwaye ingeniso yayo iyahambelana kwaye iyaqikelelwa, kwaye ibikwinqanaba lokukhula elinyukayo kule minyaka imbalwa idlulileyo.

Kodwa eyona nto itsala amehlo malunga neCroda kukuya kwisayensi yobomi, kunye nelo candelo lemisebenzi yenkampani ethatha ukubaluleka okukhulu kade, apho inkampani iye yavela njengobonelelo olubalulekileyo lwezongezo zogonyo, ngakumbi i-mRNA (isithunywa RNA). ) ezisekelwe ekulweni i-Covid-19.

Ukulandela isivumelwano seminyaka emihlanu kunye nePfizer ngoNovemba kulo nyaka uphelileyo ukubonelela ngezongezo zeziyobisi ezine, ezaziwa ngokudibeneyo njengabancedisi, ixabiso lesabelo lithathe ubomi obutsha.

Abancedisi sisithako esingasasebenziyo kumachiza kwaye benza isithako esiphakathi okanye isithuthi sokufumana isithako esisebenzayo kumalungu omzimba apho sifuneka khona.

I-Croda ibona ukuba ikhontrakthi kunye ne-Pfizer ixabisa malunga ne-100 lezigidi zeedola kulo nyaka kuphela ngesiseko se-Pfizer ehambisa i-1.3 yeebhiliyoni zeedosi zokugonya i-Covid ngo-2021.

Ngokukodwa, i-Croda's excipients ibandakanya indawo entsha yeyeza ebizwa ngokuba yi-solid lipid nanoparticles (SLNs) okanye i-lipid nanoparticles (LNPs), kwaye zenziwe ngobunjineli ukwenzela ukuba izitofu zokugonya zingene kwiiseli. Le ndlela inoveli yokuqulunqa yavunywa ukuba isetyenziswe ngo-2018.

I-Lipid nanoparticles ihlala kwindawo eqinile kwigumbi kunye nobushushu bomzimba - zizinto zokwakha zesakhiwo seseli kwaye ziquka izinto ezifana namafutha kunye namafutha. Iincinci zihamba ngobukhulu ukusuka kwi-50 ukuya kwi-1000 nm. Ngombono wendlela i-nanoparticles encinci, enye i-nanometer ilingana ne-0.0000001 millimeters.

Izabelo zeCroda kumqulu

Izabelo zenkampani yeekhemikhali ezikhethekileyo zagxuma i-10% ngoNovemba kwiindaba zokuphumelela kwenkontileka yePfizer.

I-Nanoparticles ikhusela isithako esisebenzayo ukusuka, kwelinye icala, ukutshatyalaliswa ngumzimba ekungeneni kwaye kwelinye ivumela ukuba iyeza lingene kwiiseli eziphilayo, ngoko ke zizinto ezibalulekileyo zokuqulunqwa kwamachiza esizukulwana esitsha.

Unyango olusekwe kwi-RNA (kunye ne-DNA) luba lubaluleke ngakumbi kumzi mveliso wamachiza, kunye nempumelelo yokusebenza kwezitofu zokugonya ze-mRNA ze-Covid ngowona mzekelo ubalaseleyo ukuza kuthi ga ngoku. Akukho badlali baninzi kwintsimi ye-SLN/LNP kwaye iCroda iphakathi kwabavelisi abakhulu.

Ngokungafaniyo ne-excipients zemveli, kukho ubunzima obukhulu kakhulu obubandakanyekayo kwinkqubo yokuxuba kunye neendawo ezifana nokuhluza kunye nokuzinza. Ezo zezinye zezizathu zokuba kutheni abavelisi bamachiza bengangxamelanga ukusebenzisa ii-LNP, kodwa nge-mRNA, i-RNA kunye namayeza asekwe kwi-siRNA antsokothileyo kakhulu, alukho olunye ukhetho. Impumelelo yogonyo lwe-Pfizer-Biontech kunye ne-Moderna's Covid ilivule kakhulu ibala.

Kukho ngoku abali-12 abagqatswa bogonyo lwe-mRNA ekuphuhlisweni okanye kwinqanaba lolingo lwezonyango, ngokutsho koMbutho wezeMpilo weHlabathi.

Ngokwembono yomtyali-mali ngoko, iCroda inomzila omkhulu wendlela yokukhula phambi kwayo, ethethelela ixabiso layo langoku eliphakamileyo njengoko lilinganiswe ngexabiso layo ukuya kumyinge wemivuzo engama-37.5; kwaye emva kokuba i-spurt yayo kaNovemba ithengisa i-1.4% ngaphezu kwexabiso lentengo yokuvumelana yabahlalutyi be-broker ye-6476p - ngexesha lokubhala izabelo ze-Croda zixabisa kwi-6655p, i-1.3% namhlanje.

Ukugrumba kwiziphumo zokuphela konyaka zenkampani ukuya kwi-31 kaDisemba ka-2020, ingeniso inyuke nge-1% encinci ukuya kwi-1.39 yezigidigidi zeedola, ngelixa ingeniso eshiyekileyo yehle nge-10% ukuya kwi-201 yezigidi zeedola.

Nangona kunjalo, loo manani afihla igalelo elenziwe licandelo leSayensi yoBomi, eyandisa ingeniso nge-15% ukuya kwi-£ 401 yezigidi.

Ingeniso ye-Net yatsalwa phantsi kakhulu yicandelo leshishini le-Personal Care, elibhalisa ukuwa kwe-16% ukuya kwi-£ 136 yezigidi.

Inzuzo yangaphambi kwerhafu yehla yaya kutsho kwi-£269 yezigidi xa ithelekiswa ne-£302.3 yezigidi ngonyaka ngaphambili, ngelixa ingeniso ngesabelo ngasinye yayiyi-171p ngo-2020 kwaye kuqikelelwa kwi-200p kulo nyaka nakwi-221p ngo-2022.

I-LNP yeCroda iphumelele ilandela ukufunyanwa kwayo kwe-Avanti kunye ne-Iberchem kunyaka ophelileyo kwizivumelwano ezibandakanya umxube wamatyala kunye nokubeka i-equity. I-Spanish frigracences and flavour firm Iberchem (ethengwe nge-£ 736 yezigidi) ixhasa ubuchule obukhoyo beCroda bokuqulunqa kunye ne-Avanti yinkokeli ekuhanjisweni kweziyobisi kusetyenziswa i-nanoparticles.

Oku kufunyenweyo bekuyinxalenye yesicwangciso esichaziweyo somyalelo 'wokusebenzisa isayensi ekrelekrele ukuphucula ubomi' kwaye ubeke inkampani kwindawo yokuba ngumdlali ophambili kwikamva lonikezelo lwesitofu sokugonya.

I-Croda yinto yokuthenga enamandla.

Ungathenga i-Croda nge-0% ikhomishini kwiqonga lotyalo-mali lwehlabathi eToro.