Gulani Croda chifukwa chofunikira kwambiri mu katemera wa Covid mRNA

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Croda International (CRDA), kampani yakampani yaku UK, imamveka ngati mafakitale omwe ali ndi fumbi - osasangalatsa kwenikweni koma opeza mosasunthika komanso olipira. Well Croda imalipira gawo, ngakhale ndi zokolola zochepa za 1.7% ndipo zomwe zimapeza ndizofanana komanso zodziwikiratu, ndipo zakhala zikuyenda bwino pazaka zingapo zapitazi.

Koma chomwe chimakopa chidwi cha Croda ndichofunikira chake ku sayansi ya moyo, pomwe gawo la ntchito zamakampani limakhala lofunika kwambiri mochedwa, pomwe kampaniyo idakhala ngati wothandizira wotsutsa zowonjezera za katemera, makamaka mRNA (messenger RNA Zomwe zidakhazikitsidwa kuti zalimbane ndi Covid-19.

Kutsatira mgwirizano wazaka zisanu womwe adachita ndi Pfizer kubwerera mu Novembala chaka chatha kuti apereke zowonjezera zowonjezera zinayi, zomwe zimadziwika kuti ophatikizira, mtengo wamagawo watenga mwayi watsopano wamoyo.

Zothandizila ndizomwe sizigwira ntchito mu mankhwala ndipo zimapanga sing'anga kapena galimoto yopezera chophatikizira kumagawo amthupi momwe amafunikira.

Croda akuganiza kuti mgwirizano ndi Pfizer ndiwofunika pafupifupi $ 100 miliyoni chaka chino chokha chifukwa cha Pfizer yopereka katemera wa Covid 1.3 biliyoni mu 2021.

Makamaka, othandizira a Croda amaphatikizira gawo latsopano la mankhwala lotchedwa solid lipid nanoparticles (SLNs) kapena lipid nanoparticles (LNPs), ndipo adapangidwa kuti ateteze katemera kulowa m'maselo. Njira yatsopano yophunzitsira iyi idavomerezedwa kuti igwiritsidwe ntchito mu 2018.

Lipid nanoparticles amakhalabe olimba m'chipinda chanyumba ndi kutentha kwa thupi - ndizo zomangira ma cell ndipo zimaphatikizapo zinthu monga mafuta ndi mafuta. Ma particles amakhala kukula pakati pa 50 mpaka 1000 nm. Pofuna kudziwa momwe ma nanoparticles aliri ochepa, nanometer imodzi ndi 0.0000001 millimeter.

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Magawo a kampani yapadera yamankhwala adalumphira 10% mu Novembala pankhani yakupambana kwa mgwirizano wa Pfizer.

Nanoparticles imalepheretsa kufalikira kwachangu, mbali imodzi, kuwonongedwa ndi thupi polowera komanso mbali inayo kuloleza mankhwalawo kulowa m'maselo amoyo, momwemonso ndizofunikira pakupanga mankhwala kwamibadwo yatsopano.

Njira zochiritsira za RNA (ndi DNA) zikukhala zofunikira kwambiri m'makampani ogulitsa mankhwala, ndikuchita bwino kwa katemera wa mRNA wa Covid ndiye chitsanzo chabwino kwambiri mpaka pano. Palibe osewera ambiri m'munda wa SLN / LNP ndipo Croda ndi m'modzi mwa opanga opanga.

Mosiyana ndi zopereka zachikhalidwe, pali zovuta zambiri zomwe zimakhudzidwa pakusakanikirana komanso madera monga kusefa ndi kukhazikika. Izi ndi zina mwazifukwa zomwe opanga mankhwala sanathamangire kugwiritsa ntchito LNPs, koma ndi mRNA, RNA ndi siRNA mankhwala omwe amakhala ovuta kwambiri, palibe njira ina. Kuchita bwino kwa katemera wa Pfizer-Biontech ndi Moderna wa Covid kwatsegulira mundawu modabwitsa.

Pakadali pano pali ofuna kulandira katemera 12 mRNA mwina pakukula kapena panthawi yoyesedwa, malinga ndi World Health Organisation.

Malinga ndi momwe wogulitsa amagulitsira, Croda ili ndi msewu waukulu wokula patsogolo pake, womwe umatsimikizira kuwerengera kwake kwaposachedwa monga momwe kuyerekezera ndi mtengo wake kufikira phindu la 37.5; ndipo pambuyo poti kuwonjezeka kwa Novembala kugulitsa 1.4% pamwamba pamtengo wotsutsana wa akatswiri a broker a 6476p - panthawi yolemba magawo a Croda amtengo wapatali ku 6655p, mpaka 1.3% lero.

Kukumba zotsatira zakumapeto kwa kampaniyo mpaka 31 Disembala 2020, ndalama zomwe zidapeza zidakwera 1% mpaka $ 1.39 biliyoni, pomwe ndalama zonse zidagwera 10% mpaka £ 201 miliyoni.

Komabe, ziwerengerozi zimabisa zomwe zimaperekedwa ndi gawo la Life Science, zomwe zimawonjezera ndalama ndi 15% mpaka $ 401 miliyoni.

Ndalama zonse zidakokedwa ndi gawo lazamalonda la Personal Care, lomwe lidalembetsa kugwa kwa 16% mpaka 136 miliyoni.

Phindu lamsonkho lidagwera pa $ 269 miliyoni poyerekeza ndi $ 302.3 miliyoni chaka chapitacho, pomwe gawo lililonse linali 171p mu 2020 ndipo likuyembekezeredwa 200p chaka chino ndi 221p mu 2022.

LNP ya Croda ipambana kutsatira kutsatira kwa Avanti ndi Iberchem chaka chatha pamalonda okhudzana ndi ngongole ndi kuyika chilungamo. Spanish frgracences and flavors firm Iberchem (ogulidwa $ 736 miliyoni) amalimbikitsa zomwe Croda apanga kale ndipo Avanti ndi mtsogoleri pakupereka mankhwala pogwiritsa ntchito nanoparticles.

Kupeza kumeneku kunali gawo limodzi la malangizo oyendetsedwa ndi oyang'anira 'ogwiritsira ntchito sayansi yanzeru kukonza miyoyo' ndipo yakhazikitsa kampaniyo kuti ikhale yotsogola kwambiri pakubereka katemera.

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