Sayi Croda don mahimmiyar rawa a cikin rigakafin mRNA na Covid

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Kamfanin Croda International (CRDA), kamfanin sunadarai na Burtaniya, yana jin kamar masana'antar ƙura mai ƙura - ba mai daɗi sosai ba amma mai samun ci gaba ne kuma mai biya ne. Tabbas Croda tabbas yana biyan riba, kodayake tare da ƙaramin amfanin ƙasa na 1.7% kuma abin da yake samu yana daidaito kuma ana iya faɗi, kuma sun kasance akan ƙwanƙolin ci gaba zuwa foran shekarun da suka gabata.

Amma abin da ya fi daukar ido game da Croda shi ne jigonsa zuwa ga ilimin kimiyyar rayuwa, tare da wannan sashin ayyukan kamfanin da ke dauke da mahimmancin lokaci da wuri, inda kamfanin ya fito a matsayin babban mai ba da taimako na kayan hada magunguna, musamman mRNA (manzon RNA) ) - waɗanda suka haɓaka don haɓaka Covid-19.

Bayan yarjejeniyar shekaru biyar da aka kulla tare da Pfizer a cikin watan Nuwamba na shekarar da ta gabata don samar da ƙarin magungunan ƙwayoyi guda huɗu, waɗanda aka sani tare a matsayin waɗanda ke karɓar kyauta, farashin hannun jarin ya ɗauki sabuwar yarjejeniyar rayuwa.

Masu karɓa sune abubuwan da basa aiki a cikin ƙwayoyi kuma sune matsakaici ko abin hawa don samun sinadarin aiki zuwa ɓangarorin jiki inda ake buƙata.

Kamfanin Croda ya dauki kwangilar tare da Pfizer wanda yakai kimanin dala miliyan 100 a wannan shekarar kadai a kan Pfizer wanda ya kai allurai kimanin biliyan 1.3 na Covid a 2021.

Musamman, wadanda suka kware a Croda sun hada da wani sabon fannin magani da ake kira solid lipid nanoparticles (SLNs) ko lipid nanoparticles (LNPs), kuma an kirkiresu ne don bawa allurar rigakafi damar shiga sel. An yarda da wannan sabon salon don kirkirar a 2018.

Abubuwan da ke cikin lipid sun kasance cikin tabbataccen yanayi a ɗaki da zafin jiki - sune tubalin ginin ƙirar kwayar halitta kuma sun haɗa da abubuwa kamar mai da mai. Barbashi suna cikin girman daga 50 zuwa 1000 nm. Don ra'ayin yadda ƙananan abubuwa suke, nanometer ɗaya yayi daidai da millimeter 0.0000001.

Croda yayi hannun jari a kan nadi

Hannayen jarin kamfanin sunadarai na musamman sun tashi 10% a cikin Nuwamba a kan labarin cin nasarar kwangilar Pfizer.

Nanoparticles suna hana shigowar aiki daga, a gefe guda, jiki ya lalata shi yayin shigarwa kuma ɗayan yana ba da damar maganin ya shiga cikin ƙwayoyin rai, don haka mahimman abubuwa ne na ƙirƙirar ƙwayoyin zamani.

RNA (da DNA) -basirar ilimin asali suna zama masu mahimmanci a masana'antar magunguna, tare da nasarar tasiri na rigakafin mRNA don Covid shine mafi kyawun misali har zuwa yau. Babu 'yan wasa da yawa a cikin filin SLN / LNP kuma Croda yana cikin manyan masana'antun.

Ba kamar tare da tsofaffin ɗalibai na gargajiya ba, akwai mawuyacin mawuyacin hali da ke tattare da aikin haɗawa da kuma yankuna kamar ƙwarewa da kwanciyar hankali. Waɗannan su ne wasu dalilai da ya sa masana'antun magunguna ba su hanzarta yin amfani da LNPs ba, amma tare da magungunan mRNA, RNA da siRNA waɗanda suke da haɗari sosai, babu wani zaɓi. Nasarar Pfizer-Biontech da Moderna's Covid alluran ta buɗe filin sosai.

A halin yanzu akwai 'yan takarar allurar rigakafin mRNA 12 ko dai a ci gaba ko a matakin gwaji na asibiti, a cewar Hukumar Lafiya ta Duniya.

Daga mahangar mai saka jari a lokacin, Croda yana da babbar hanyar ci gaba a gabanta, wanda ke ba da hujjar ƙimar da take a yanzu kamar yadda aka auna ta da farashinta zuwa rabon kashi 37.5; kuma bayan ƙarshen watan Nuwamba yana cinikin 1.4% sama da ƙididdigar ƙididdigar ƙididdigar masu sharhi na 6476p - a lokacin da ake rubuta hannun jarin Croda ana farashinsa akan 6655p, sama da 1.3% a yau.

Nemi cikin sakamakon ƙarshen kamfanin zuwa 31 Disamba 2020, kuɗaɗen shiga sun ƙaru da ƙarami 1% zuwa £ 1.39 biliyan, yayin da kuɗin shiga ya faɗi 10% zuwa £ miliyan 201.

Koyaya, waɗannan ƙididdigar suna ɓoye gudummawar da sashen Kimiyyar Rayuwa ke bayarwa, wanda ya haɓaka kuɗaɗen shiga da 15% zuwa to 401 miliyan.

Incomeididdigar kuɗin shiga ya ragu da yawa ta ɓangaren kasuwancin Kula da Kai, wanda ya yi rajistar faduwar 16% zuwa £ 136 miliyan.

Riba ta haraji ta fadi zuwa £ 269 miliyan a kan £ 302.3 miliyan a shekara a baya, yayin da ribar da aka samu ta kashi 171p a 2020 kuma an yi hasashen a 200p a wannan shekara da 221p a 2022.

Lda ta Croda ta LNP ta biyo bayan sayen Avanti da Iberchem a shekarar da ta gabata a cikin yarjejeniyar da ta shafi cakuda bashi da sanya daidaito. Frenfences na Spain da kamfanin dandano na Iberchem (an siya shi akan £ 736 miliyan) ya ƙarfafa ƙwarewar ƙirar Croda kuma Avanti jagora ne wajen isar da ƙwayoyi ta amfani da ƙananan abubuwa.

Abubuwan da aka samo sune wani ɓangare na mahimman dabarun sarrafawa na 'amfani da ingantaccen kimiyya don haɓaka rayuka' kuma ya sanya kamfanin ya zama babban ɗan wasa a gaba na bayar da allurar rigakafin.

Croda siye ne mai ƙarfi.

Kuna iya siyan Croda don kwamiti na 0% a dandalin saka hannun jari na duniya eToro.